Biolex MB40

Biolex-MB40 is a commercial prebiotic which contains 10-15% mannan oligosaccharide (MOS) and 25-30% 1,3/1,6-β-D-glucan.

Oligosaccharides, β-glucans and MOS isolated from the cell wall of Saccharomyces cerevisiae yeast exert immunostimulatory effects by binding to specific receptors on the surface of effector cells. β-glucans stimulate a wide range of immune responses, such as cytokine release, generation of ROS, generation of NO and release of arachidonic acid metabolites.

According to Seifert and Watzl (2007), MOS partially binds to the carbohydrate receptors of intestinal epithelial cells and, after absorption, to the receptors of immune system cells to stimulate the local and systemic immune response. The direct binding of MOS could take place through several receptors, including TLR, mannose receptors, galectin family receptors  and transmembrane mucins (MUC1 and MUC40).

The above mechanism could explain the high effectiveness of MOS in limiting the colonization of small and large intestines by pathogenic bacteria with type 1 fimbriae which prevent those microorganisms (e.g. Salmonella,
Clostridium, Escherichia coli) from becoming attached to mannan-dependent enterocyte receptors in the intestinal epithelium. The fimbriae (lectins) of pathogenic bacteria also bind to mannans and are excreted as undigested particles with feces. In monocytes, macrophages, neutrophils and microglia, dectin-1 plays the role of a carbohydrate receptor that directly binds MOS (Brown 2006), which stimulates non-specific and specific immune responses.

 APPLICATION: It is added to the feed during its production at compound feed plants or in feed mills, by uniform mixing, at the rate of:

Cattle:

  • calves (repair young) - 1-2 kg/t;
  • fattening calves - 1-2 kg/t;
  • dairy cows - 1-2 kg/t.

Pigs:

  • piglets - 1-1.5 kg/t;
  • sows - 0.5-1.5 kg/t;
  • fattening pigs - 0.5-1 kg/t.

Bird:

  • laying hens - 0.2-1.0 kg/t;
  • broilers - 0.2-1.0 kg/t;
  • turkeys, geese - 0.5-2.0 kg/t.

 

 

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